Sildenafil citrate, commonly known by the brand name, is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. It works by improving blood flow to the penis, helping to achieve and maintain an erection during sexual activity.

Dosage and Administration

Sildenafil is available in 25mg, 50mg, and 100mg strengths.

• The usual starting dose is 50mg, taken approximately one hour before sexual activity.
• Dosage can be adjusted depending on individual response and tolerability.
• Take only one tablet in 24 hours, with or without food.
• Avoid grapefruit juice, as it can increase the risk of side effects.
• A high-fat meal may delay onset of action.

Effectiveness

Sildenafil has been shown to be effective in up to 80% of men with ED, with effects typically noticeable within 30 to 60 minutes, and lasting for up to 4–5 hours.

Side Effects

Common side effects include:

• Headache
• Flushing
• Nasal congestion
• Indigestion

Less common but serious effects include visual disturbances, hearing changes, or prolonged erections. Seek medical attention if severe or persistent side effects occur.

Contraindications

Sildenafil should not be used by those:

• Taking nitrates for chest pain
• With severe heart or liver conditions
• Under 18 years of age
• With certain medication interactions (e.g. alpha-blockers, antifungals, antibiotics)

Interactions

Inform your doctor of all medications and supplements before use. Interactions may occur with:

• Nitrates
• Alpha-blockers
• Some antibiotics and antifungal medicines

Alcohol and Heart Conditions

Avoid excessive alcohol while taking sildenafil, as it can lower blood pressure and increase side effect risk. Use with caution if you have any heart-related conditions.

Availability and Cost

Sildenafil is available by prescription only in the UK.

• Generic versions are more affordable than branded Viagra.
• Supplied by licensed UK pharmacies such as Online Chemist.
• Avoid counterfeit products from unregulated websites.

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Uses of Sildenafil

Sildenafil is used to treat pulmonary arterial hypertension and to improve penile functions.

Therapeutic Category

Sildenafil: Phosphodiesterase type 5 (PDE 5) inhibitors

How Sildenafil works

Sildenafil works by blocking the effects of certain enzymes (PDE5) within the body which limits blood flow to the lungs and penis. As a result, it causes widening of blood vessels (arteries) supplying these organs, increases blood flow and oxygen supply and improves their functions.

Common side effects of Sildenafil

• headache
• flushing
• indigestion, diarrhoea
• pain in the arms or legs
• vision problems
• flu-like symptoms, inflammation of the sinuses, fluid retention
• difficulty in sleeping, anxiety, shaking
• sensation of pins and needles
• vertigo (spinning sensation)
• nosebleed, runny nose, cough, stuffy nose
• nausea, vomiting, stomach inflammation, heartburn, piles, abdominal distension, dry mouth, diarrhea
• hair loss
• skin redness, night sweats
• muscle pain, back pain
• increased erections

When to consult your doctor

Consult your doctor if you experience:

• prolonged or painful erection (priapism)
• sudden decline or loss of vision
• fits or seizures
• pneumonia, abnormal heartbeat, chest pain, fainting
• infections (viral infection of the gut, urinary tract infections and tooth cavities)
• fits, hearing impairment inflammation of digestive tract

Health Tips for Sildenafil

• Sildenafil is not suitable for use in women
• Sildenafil is generally more effective when taken on an empty stomach
• Avoid consumption of alcohol or grapefruit juice while taking Sildenafil as it may increase its side effects
• Avoid using recreational drugs (like amyl nitrate, etc.) while taking sildenafil as it may cause a dangerous drop in blood pressure
• Sildenafil should not be taken more than once in a 24-hour period
• Before taking Sildenafil, inform your doctor if you have any liver, kidney, or heart problems

estine Bohemian Drug Info:

What is Sildenafil?

Sildenafil is a potent FDA-approved medication for the treatment of pulmonary arterial hypertension, and to varying degrees of preference. In addition to its well-known clinical uses, Sildenafil also constitutes a family of medicines called phosphodiesterase type 5 (PDE 5) inhibitors. These drugs are used to treat pulmonary arterial hypertension (high blood pressure in the arteries of the lungs) and to improve penile functions. Sildenafil is a member of the drug class's PDE 5 inhibitors.

cember 2017 update:

Sildenafil now represents a family of drugs known as PDE 5 inhibitors. They are also known as "antibiotics" and are used to treat infections, autoimmune disorders, inflammatory conditions and infections of the urinary tract, respiratory tract and vagina.

Use in Children: How to Use Sildenafil

• Read the Patient Information Leaflet if available from your local pharmacy or report any existing or recent illnesses
• Take Sildenafil as prescribed by your doctor.
• In adults, Sildenafil is available as tablets of 200mg, 300mg and 400mg.
• The dosage and duration of treatment should be as directed by your doctor.

estine Drug Info:

How to take Sildenafil

• Swallow the tablet with a glass of water or a glass of milk. Just after the dose you should have a firm erection.

Drug Interaction of Viagra 100mg Tablet

Drug-Drug Interaction

Chloramphenicol

The use of this drug is contraindicated because the use of chloramphenicol will increase the effect of Sildenafil by affecting the patient hepatic and intestinal enzyme metabolism.

Isosorbide dinitrate

The use of this drug is contraindicated because the combination of this drug either increases the effects of the other by vasodilation which leads to fatal hypotension.

Nitroprusside sodium

The use of this drug is contraindicated because the combination of this drug either increases the effects of the others by pharmacodynamic synergism.

Enzalutamide

Use alternative drugs because the use of enzalutamide will decrease the effect of Sildenafil by affecting patient hepatic and intestinal enzyme metabolism.

Acetazolamide

Therapy should be administered with caution because the use of Sildenafil increases the effect of acetazolamide by pharmacodynamic synergism and it also increases the risk of hypotension.

Drug-Food Interaction

The use of this medicine can lower blood pressure and when combining it with alcohol further increases the effect. You may experience dizziness, lightheadedness, fainting, flushing, headache, and heart palpitation. Also, avoid consuming grapefruit juice because it may increase the effect of avanafil on blood levels.

Drug-Disease Interaction

Cardiovascular disease:

The use of phosphodiesterase-5 enzyme inhibitors is contraindicated in patients with cardiovascular disease. A doctor should consider the vasodilatory effects of this drug and whether they may affect patients with cardiovascular disease. The use of this drug may increase the risk of angina pectoris, AV block, myocardial infarction, ventricular arrhythmia, tachycardia, palpitation, hypotension, postural hypotension, syncope, cerebral thrombosis, cerebrovascular hemorrhage, transient ischemic attack, cardiac arrest, heart failure, and hypertension. These events can occur during or after sexual activity.

Renal dysfunction:

Therapy should be administered with caution in patients with severe renal disease or on renal dialysis. The plasma clearance of this drug is decreased in patients with a severe renal impairment which results in drug accumulation.

Liver diseases:

The use of this drug is not recommended for patients with severe hepatic impairment because the pharmacokinetic disposition of this drug has not been assessed in patients with severe hepatic impairment.

Appropriate intake

The use of phosphodiesterase-5 enzyme inhibitors is not recommended for patients with cardiovascular disease. A doctor should consider the vasodilatory effects of this drug and whether they may increase the risk of angina pectoris, AV block, myocardial infarction, ventricular arrhythmia, tachycardia, postural hypotension, cerebral thrombosis, cerebrovial hemorrhage, transient ischemic attack, cardiac arrest, and hypertension.

Renal function:

Therapy should be administered with caution in patients with a severe renal disease or on renal dialysis. The plasma clearance of this drug is decreased in patients with]$ Ain al faso with renal insufficiency

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